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Finding that the concentration or activity of proteins differs between those who handle drugs as expected and those who do not proves neither that the associations are genetic nor that they are causally related to the altered response Differences in the function of enzymes or proteins that affect drug handling may result from posttranslational (nongenetic) modi cation (Banks et al, 2000), which might be in uenced by other drugs or other exogenous factors The persistence of variation in cultured cells makes the role of exogenous factors less likely An inherited basis is suggested by studies in healthy rst-degree relatives of patients with altered drug handling When some of these relatives have the same abnormality in protein concentration or activity as the patient, and the proportion with the abnormality is consistent with Mendelian inheritance, a single gene of high penetrance is probably responsible.

16810 The action of the above policy would be triggered, resulting in an alert to the operator which would contain the following descriptive text: Excessive traf c on subnet 19216810 Example 2 In this example, consider a situation where the network con guration must be changed at speci c times of day This scenario could arise, for example, if application requirements are very different during the day and night Take the case where a network is con gured to support DiffServ QoS, and certain percentages of bandwidth are reserved for different types of traf c The percentages of traf c dedicated to speci c types of traf c depend on the expected traf c mix in the network If application requirements exhibit a marked difference based on time of day, then it makes sense to recon gure the bandwidth allocations based on time of day.

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A realistic example of this is that during the night, certain les may need to be backed up over the network, and therefore there will be large volumes of FTP traf c at night; and during the day, more bandwidth must be dedicated to real-time voice and video applications, which are not that prevalent during night hours Policies can be put in place to recon gure the network based on time of day A special kind of event, a timed event, can be generated by a simple application at the desired times speci ed in a policy The following policies can trigger con guration changes at speci c times of day:.

This is also suggested when studies of populations of those using a drug indicate that the distribution of its concentration in the blood, or of a metabolite or of one of the enzymes that metabolizes the drug, is bimodal (Evans, 1963; Turner et al, 2001) One peak is usually due to heterozygotes and the less frequent homozygote and the other to the more common homozygote If the population surveyed is suf ciently large (several hundred), the less frequent homozygotes may constitute a third peak, provided that the enzyme activity differs between them and heterozygotes.

counter is initially idle and is ready to accept new customers. Therefore, its initial state c[k].sta is set to 0. The following code fragment performs the operation:

openness of the core elements (routers), and the attractive economics of computing at the edge of the network; interestingly, these are all reasons cited as weaknesses of traditional telecommunications networks (Isenberg 1997; Lazar 1997) A degenerate (and arguable) example of an overlay on IP is the DNS; however, application layer multicast, anonymizers, and Content Distribution Networks (CDN) are increasingly prevalent and sophisticated With VoP designs, these overlay networks can serve both PSTN and IP-based networks Similarly, it is clear that mobile terminals and the RAN are increasing in intelligence For example, the latter has the ability to do more ne-grained power control, soft handoffs, and the like Recently, there has been a surge of activity in integrating IEEE 80211b based wireless access networks that are far simpler than traditional cellular base stations.

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